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The Dark Side of Wheat – New Perspectives On Celiac Disease and Wheat Intolerance

The Dark Side of Wheat - New Perspectives On Celiac Disease and Wheat Intolerance

The Dark Side of Wheat - New Perspectives On Celiac Disease and Wheat Intolerance | Dark-side-of-Wheat | General Health Natural Medicine Sleuth Journal Special Interests

The globe-spanning presence of wheat and its exalted standing amongst secular and sacred establishments alike differentiates this meals from all others presently loved by people. But the unparalleled rise of wheat because the very catalyst for the emergence of historic civilization has not occurred with no nice worth 

Whereas wheat was the engine of civilization’s enlargement and was glorified as a “necessary food,” each within the bodily (employees of life) and religious sense (the physique of Christ), these affected by celiac illness live testimony to the lesser recognized darkish aspect of wheat. A research of celiac illness and might assist unlock the thriller of why trendy man, who dines every day on the desk of wheat, is the sickest animal but to have arisen on this unusual planet of ours.

The Celiac Iceberg

Celiac illness (CD) was as soon as thought-about a particularly uncommon affliction, restricted to people of European descent. As we speak, nevertheless, a rising quantity of research point out that celiac illness is discovered all through the world at a fee of as much as 1 in each 100 individuals, which is a number of orders of magnitude greater than beforehand estimated.   

These findings have led researchers to visualise CD as an iceberg. The tip of the iceberg represents the comparatively small quantity of the world’s inhabitants whose gross presentation of medical signs typically results in the analysis of celiac illness. That is the classical case of CD characterised by gastrointestinal signs, malabsorption and malnourishment. It’s confirmed with the “gold standard” of an intestinal biopsy. The submerged center portion of the iceberg is essentially invisible to classical medical analysis, however to not trendy serological screening strategies within the type of antibody testing. This center portion consists of asymptomatic and latent celiac illness in addition to “out of the intestine” varieties of wheat intolerance. Lastly, on the base of this large iceberg sits roughly 20-30% of the world’s inhabitants – those that have been discovered to hold the HLA-DQ locus of genetic susceptibility to celiac illness on chromosome 6.*

The “Celiac Iceberg” might not merely illustrate the issues and points related to analysis and illness prevalence, however might symbolize the necessity for a paradigm shift in how we view each CD and wheat consumption amongst non-CD populations.

First allow us to tackle the normal view of CD as a uncommon, however clinically distinct species of genetically-determined illness, which I consider is now operating itself aground upon the rising, post-Genomic perspective, whose implications for understanding and treating illness are Titanic in proportion. 

It Is Not Within the Genes, However What We Expose Them To

Regardless of widespread misconceptions, monogenic illnesses, or illnesses that end result from errors within the nucleotide sequence of a single gene are exceedingly uncommon. Maybe just one% of all illnesses fall inside this class, and Celiac illness is just not one of them. In reality, following the completion of the Human Genome Undertaking (HGP) in 2003 it’s not correct to say that our genes “cause” illness, any greater than it’s correct to say that DNA alone is adequate to account for all of the proteins in our physique. Regardless of preliminary expectations, the HGP revealed that there are solely 20,000-25,000 genes in human DNA (genome), slightly than the 100,000 + believed essential to encode the 100,000 + proteins discovered within the human physique (proteome).

The “blueprint” mannequin of genetics: one gene → one protein → one mobile conduct, which was as soon as the holy grail of biology, has now been supplanted by a mannequin of the cell the place epigenetic elements (actually: “beyond the control of the gene”) are main in figuring out how DNA will probably be interpreted, translated and expressed. A single gene can be utilized by the cell to precise a mess of proteins and it isn’t the DNA alone that determines how or what genes might be expressed. Relatively, we should look to the epigenetic elements to know what makes a liver cell totally different from a pores and skin cell or mind cell. All of these cells share the very same Three billion base pairs that make up our genome, however it’s the epigenetic elements, e.g. regulatory proteins and post-translational modifications, that make the willpower as to which genes to activate and which to silence, leading to every cell’s distinctive phenotype. Furthermore, epigenetic elements are immediately and not directly influenced by the presence or absence of key vitamins within the weight loss plan, in addition to exposures to chemical compounds, pathogens and different environmental influences. 

In a nutshell, what we eat and what we’re uncovered to in our surroundings instantly impacts our DNA and its expression.

Inside the scope of this new perspective even classical monogenic illnesses like cystic fibrosis (CF) might be seen in a brand new, extra promising mild. In CF many of the opposed modifications that outcome from the faulty expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene could also be preventable or reversible, owing to the truth that the misfolding of the CFTR gene product has been proven to bear partial or full correction (within the rodent mannequin) when uncovered to phytochemicals present in turmeric, cayenne, and soybean Furthermore, dietary deficiencies of seleniun, zinc, riboflavin, vitamin e, and so forth. within the womb or early in life, might “trigger” the defective expression or folding patterns of the CFTR gene in cystic fibrosis which could in any other case have prevented epigenetic activation. This is able to clarify why it’s potential to stay into one’s late seventies with this situation, as was the case for Katherine Shores (1925-2004). The implications of these findings are fairly extraordinary: epigenetic and not genetic elements are main in figuring out illness consequence. Even when we exclude the likelihood of reversing sure monogenic illnesses, the essential lesson from the post-Genomic period is that we will’t blame our DNA for inflicting illness. Somewhat, it might have extra to do with what we select to show our DNA to.

Celiac Disease Revisited

What all of this implies for CD is that the genetic susceptibility locus, HLA-DQ, doesn’t by itself decide the precise medical consequence of the illness. As an alternative of being ‘the cause,’ the HLA genes could also be activated as a consequence of the illness course of. Thus, we might have to shift our epidemiological focus from viewing this as a classical “disease” involving a passive topic managed by aberrant genes, to viewing it as an expression of a pure, protecting response to the ingestion of one thing that the human physique was not designed to eat.

If we view celiac illness not as an unhealthy response to a wholesome meals, however as a wholesome response to an unhealthy meals, classical CD signs like diarrhea might make extra sense. Diarrhea may be the physique’s solution to scale back the period of publicity to a toxin or pathogen, and villous atrophy could be the physique’s method of stopping the absorption and therefore, the systemic results of continual publicity to wheat. 

I consider we might be higher served by viewing the signs of CD as expressions of bodily intelligence slightly than deviance. We should shift the main target again to the illness set off, which is wheat itself.

Individuals with celiac illness may very well have a bonus over the apparently non-afflicted as a result of those that are “non-symptomatic” and whose wheat intolerance goes undiagnosed or misdiagnosed as a result of they lack the classical signs and might endure in methods which are equally or extra damaging, however expressed extra subtly, or in distant organs. Inside this view celiac illness can be redefined as a protecting (wholesome?) response to publicity to an inappropriate substance, whereas “asymptomatic” ingestion of the grain with its concomitant “out of the intestine” and principally silent signs, can be thought-about the unhealthy response insofar because it doesn’t sign in an apparent and acute method that there’s a drawback with consuming wheat. 

It’s potential that celiac illness represents each an excessive response to a worldwide, species-specific intolerance to wheat that all of us share in various levels. CD signs might mirror the physique’s innate intelligence when confronted with the consumption of a substance that’s inherently poisonous. Let me illustrate this level utilizing wheat germ agglutinin (WGA), for instance. 

WGA is assessed as a lectin and is understood to play a key position in kidney pathologies, comparable to IgA nephropathy. Within the article: “Do dietary lectins cause disease?” the Allergist David L J Freed factors out that WGA binds to “glomerular capillary walls, mesangial cells and tubules of human kidney and (in rodents) binds IgA and induces IgA mesangial deposits,” indicating that wheat consumption might result in kidney injury in prone people. Certainly, a research from the Mario Negri Institute for Pharmacological Analysis in Milan Italy revealed in 2007 within the Worldwide Journal of Most cancers checked out bread consumption and the danger of kidney most cancers. They discovered that those that consumed probably the most bread had a 94% larger danger of creating kidney most cancers in comparison with those that consumed the least bread. Given the inherently poisonous impact that WGA might have on kidney perform, it’s potential that in sure genetically predisposed people (e.g. HLA-DQ2/DQ8) the physique – in its innate intelligence – makes an government choice: both proceed to permit injury to the kidneys (or probably different organs) till kidney failure and speedy demise outcome, or launch an autoimmune assault on the villi to stop the absorption of the offending substance which leads to a protracted although comparatively malnourished life. That is the reason sometimes given for the physique’s reflexive formation of mucous following publicity to sure extremely allergenic or probably poisonous meals, e.g. dairy merchandise, sugar, and so forth? The mucous coats the offending substance, stopping its absorption and facilitating protected elimination by way of the gastrointestinal tract. From this attitude the HLA-DQ locus of illness susceptibility within the celiac just isn’t merely activated however utilized as a defensive adaptation to continuous publicity to a dangerous substance. In those that don’t have the HLA-DQ locus, an autoimmune destruction of the villi won’t happen as quickly, and publicity to the universally poisonous results of WGA will possible go unabated till silent injury to distant organs results in the analysis of a illness that’s apparently unrelated to wheat consumption.  

Loss of kidney perform might solely be the “tip of the iceberg,” relating to the potential hostile results that wheat proteins and wheat lectin can generate within the physique. If kidney most cancers is a possible risk, then different cancers might ultimately be linked to wheat consumption as properly. This correlation would fly within the face of globally sanctioned and reified assumptions concerning the inherent advantages of wheat consumption. It will require that we droop cultural, socio-economic, political and even spiritual assumptions about its inherent advantages. In some ways, the reassessment of the worth of wheat as a meals requires a William Boroughs-like second of surprising readability once we understand “in a frozen moment….what is on the end of every fork.” Let’s take a better take a look at what’s on the top of our forks.

Our Biologically Inappropriate Food regimen

In a earlier article, I mentioned the position that wheat performs as an industrial adhesive (e.g. paints, paper mache’, and e-book binding-glue) as a way to illustrate the purpose that it is probably not such a very good factor for us to eat. The drawback is implicit within the phrase gluten, which accurately means “glue” in Latin and in phrases like pastry and pasta, which derives from wheatpaste, the unique concoction of wheat flour and water which made such good plaster in historic occasions. What provides gluten its adhesive and difficult-to-digest qualities are the excessive ranges of disulfide bonds it accommodates. These similar sulfur-to-sulfur bonds are present in hair and vulcanized rubber merchandise, which everyone knows are troublesome to decompose and are liable for the sulfurous odor they provide off when burned. 

There shall be 676 million metric tons of wheat produced this yr alone, making it the first cereal of temperate areas and third most prolific cereal grass on the planet. This international dominance of wheat is signified by the Meals & Agricultural Group’s (FAO) (the United Nation’s worldwide company for defeating starvation) use of a head of wheat as its official image. Any effort to indict the credibility of this “king of grains” will show difficult. As Rudolf Hauschka as soon as remarked, wheat is “a kind of earth-spanning organism.” It has huge socio-economic, political, and cultural significance. For instance, within the Catholic Church, a wafer made of wheat is taken into account irreplaceable because the embodiment of Christ.

Our dependence on wheat is matched solely by its dependence on us. As Europeans have unfold throughout the planet, so has this grain. We now have assumed complete duty for all phases of the wheat life cycle: from keeping off its pests; to offering its preferrred rising circumstances; to facilitating copy and enlargement into new territories. We’ve develop into so inextricably interdependent that neither species is sustainable at present inhabitants ranges with out this symbiotic relationship.  

It’s this co-dependence which will clarify why our tradition has for therefore lengthy persistently confined wheat intolerance to categorically distinct, “genetically-based” illnesses like “celiac.” These categorizations might shield us from the belief that wheat exerts an enormous quantity of deleterious results on human well being in the identical approach that “lactose intolerance” distracts consideration from the deeper issues related to the casein protein present in cow’s milk. Quite than see wheat for what it very nicely could also be: a biologically inappropriate meals supply, we “blame the victim,” and search for genetic explanations for what’s improper with small subgroups of our inhabitants who’ve the obvious types of intolerance to wheat consumption, e.g. celiac illness, dermatitis herpetiformis, and so on.   The medical justification for these classifications could also be secondary to financial and cultural imperatives that require the inherent issues related to wheat consumption be minimized or occluded.

Most likely the celiac genotype represents a surviving vestigial department of a as soon as common genotype, which by way of accident or intention, have had via successive generations solely restricted publicity to wheat. The celiac genotype, little question, survived by way of quite a few bottlenecks or “die offs” represented by a dramatic shift from hunted and foraged/gathered meals to gluten-grain consumption, and for no matter purpose merely didn’t have sufficient time to adapt or choose out the gluten-grain incompatible genes. The celiac response might certainly mirror a previous, species-wide intolerance to a novel meals supply: the seed storage type of the monocotyledonous cereal grasses which our species solely started consuming 1-500 generations in the past on the creation of the Neolithic transition (10-12,000 BC). Allow us to return to the picture of the celiac iceberg for larger clarification.

Our Submerged Grain-Free Prehistory

The iceberg metaphor is a wonderful strategy to broaden our understanding of what was as soon as thought-about to be a very uncommon illness into one which has statistical relevance for us all, however it has a couple of limitations. For one, it reiterates the generally held view that Celiac is a numerically distinct illness entity or “disease island,” floating alongside different numerically distinct illness “ice cubes” within the huge sea of regular well being. Although correct in describing the sense of social and psychological isolation many of the bothered really feel, the celiac iceberg/situation is probably not a definite illness entity in any respect. 

Though the HLA-DQ locus of illness susceptibility on chromosome 6 presents us a spot to challenge blame, I consider we have to shift the emphasis of duty for the situation again to the illness “trigger” itself: specifically, wheat and different prolamine wealthy grains, e.g. barley, rye, spelt, and oats. With out these grains the standard afflictions we name celiac wouldn’t exist. Inside the scope of this view the “celiac iceberg” shouldn’t be truly free floating however an outcropping from a whole submerged subcontinent, representing our long-forgotten (cultural time) however comparatively current metabolic prehistory as hunters-and-gatherers (organic time), the place grain consumption was, in all probability, non-existent, besides in situations of near-starvation.

The strain on the celiac to be seen as an distinctive case or deviation might have every thing to do with our preconscious perception that wheat, and grains as an entire are the “health foods,” and little or no to do with a rigorous investigations of the details.

Grains have been heralded since time immemorial because the “staff of life,” when in truth they’re extra precisely described as a cane, precariously propping up a physique starved of the nutrient-dense, low-starch greens, fruits, edible seeds and meats, they’ve so completely supplanted (c.f. Paleolithic Weight loss plan). Most of the illnesses of affluence, e.g. sort 2 diabetes, coronary coronary heart illness, most cancers, and so on. could be linked to the consumption of a grain-based food plan, together with secondary “hidden sources” of grain consumption in grain-fed fish, poultry, meat and milk merchandise.

Our trendy perception that grains make for good meals, is just not supported by the details. The cereal grasses are inside a completely totally different household: monocotyledonous (one leafed embryo) than that from which our physique sustained itself for hundreds of thousands of years: dicotyledonous (two leafed embryo). The preponderance of scientific proof factors to a human origin within the tropical rainforests of Africa the place dicotyledonous fruits would have been out there for yr spherical consumption. It will not have been monocotyledonous crops, however the flesh of hunted animals that might have allowed for the migration out of Africa 60,000 years in the past into the northern latitudes the place vegetation would have been sparse or non-existent throughout winter months. Accumulating and cooking grains would have been unbelievable given the low nutrient and caloric content material of grains and the insufficient improvement of pyrotechnology and related cooking utensils essential to eat them with any effectivity. It was not till the top of the final Ice Age 20,000 years in the past that our human ancestors would have slowly transitioned to a cereal grass based mostly weight-reduction plan coterminous with emergence of civilization. 20,000 years might be not sufficient time to completely adapt to the consumption of grains. Even animals like cows with a head begin of hundreds of years, having advanced to graze on monocotyledons and outfitted as ruminants with the four-chambered fore-stomach enabling the breakdown of cellulose and anti-nutrient wealthy crops, aren’t designed to eat grains. Cows are designed to eat the sprouted mature type of the grasses and not their seed storage type. Grains are so acidic/poisonous in response that solely grain-fed cattle are vulnerable to creating extreme acidosis and subsequent liver abscesses and infections, and so on. Feeding wheat to cattle offers a good higher problem:

Beef: Feeding wheat to ruminants requires some warning because it tends to be extra apt than different cereal grains to trigger acute indigestion in animals that are unadapted to it. The main drawback seems to be the excessive gluten content material of which wheat within the rumen may end up in a “pasty” consistency to the rumen contents and lowered rumen motility. – (supply: Ontario ministry of Agriculture meals & Rural affairs)

Seeds, in any case, are the “babies” of these crops, and are invested with not solely the whole hope for continuance of its species, however an enormous armory of anti-nutrients to assist it accomplish this activity: poisonous lectins, phytates and oxalates, alpha-amalyase and trypsin inhibitors, and endocrine disrupters. These not so appetizing phytochemicals allow crops to withstand predation of their seeds, or a minimum of stopping them from “going out without a punch.”  

Wheat: An Exceptionally Unwholesome Grain

Wheat presents a particular case insofar as wild and selective breeding has produced variations which embrace as much as 6 units of chromosomes (3x the human genome value!) succesful of producing an enormous quantity of proteins every with a definite potentiality for antigenicity. Widespread bread wheat (Triticum aestivum), for example, has over 23,788 proteins cataloged so far. In truth, the genome for widespread bread wheat is definitely 6.5 occasions bigger than that of the human genome!

With as much as a 50% improve in gluten content material of some varieties of wheat, it’s superb that we proceed to think about “glue-eating” a traditional conduct, whereas wheat-avoidance is left to the “celiac” who continues to be perceived by the bulk of well being care practitioners as mounting a “freak” response to the consumption of one thing intrinsically healthful.

Fortunately we don’t have to depend on our instinct, and even (not so) widespread sense to attract conclusions concerning the inherently unhealthy nature of wheat. A variety of investigation has occurred over the previous decade revealing the issue with the alcohol soluble protein element of wheat generally known as gliadin, the sugar-binding protein often known as lectin (Wheat Germ Agglutinin), the exorphin generally known as gliadomorphin, and the excitotoxic potentials of excessive ranges of aspartic and glutamic acid present in wheat. Add to those the anti-nutrients present in grains similar to phytates, enzyme inhibitors, and so forth. and you’ve got a substance which we might extra appropriately contemplate the farthest factor from healthful. 

The the rest of this text will exhibit the next opposed results of wheat on each celiac and non-celiac populations: 1) wheat causes injury to the intestines 2) wheat causes intestinal permeability Three) wheat has pharmacologically lively properties Four) wheat causes injury that’s “out of the intestine” affecting distant organs 5) wheat induces molecular mimicry 6) wheat incorporates excessive concentrations of excitoxins.


Gliadin is assessed as a prolamin, which is a wheat storage protein excessive within the amino acids proline and glutamine and soluble in robust alcohol options. Gliadin, as soon as deamidated by the enzyme Tissue Transglutaminase, is taken into account the first epitope for T-cell activation and subsequent autoimmune destruction of intestinal villi. But gliadin doesn’t have to activate an autoimmune response, e.g. Celiac illness, in an effort to have a deleterious impact on intestinal tissue.

In a research revealed in GUT in 2007 a gaggle of researchers requested the query: “Is gliadin really safe for non-coeliac individuals?” So as to check the speculation that an innate immune response to gliadin is widespread in sufferers with celiac illness and with out celiac illness, intestinal biopsy cultures have been taken from each teams and challenged with crude gliadin, the gliadin artificial 19-mer (19 amino acid lengthy gliadin peptide) and 33-mer deamidated peptides. Outcomes confirmed that each one sufferers with or with out Celiac illness when challenged with the varied varieties of gliadin produced an interleukin-15-mediated response. The researchers concluded:

“The data obtained in this pilot study supports the hypothesis that gluten elicits its harmful effect, throughout an IL15 innate immune response, on all individuals [my italics].”

The main distinction between the 2 teams is that the celiac illness sufferers skilled each an innate and an adaptive immune response to the gliadin, whereas the non-celiacs skilled solely the innate response. The researchers hypothesized that the distinction between the 2 teams could also be attributable to larger genetic susceptibility on the HLA-DQ locus for triggering an adaptive immune response, greater ranges of immune mediators or receptors, or maybe higher permeability within the celiac gut. It’s potential that over and above the likelihood of larger genetic susceptibility, most of the variations are from epigenetic elements which might be influenced by the presence or absence of sure vitamins within the eating regimen. Different elements akin to publicity to NSAIDs like naproxen or aspirin can profoundly improve intestinal permeability within the non-celiac, rendering them prone to gliadin’s potential for activating secondary adaptive immune responses. This will likely clarify why in as much as 5% of all instances of classically outlined celiac illness the standard HLA-DQ haplotypes usually are not discovered. Nevertheless, figuring out the elements related higher or lesser levels of susceptibility to gliadin’s intrinsically poisonous impact ought to be a secondary to the truth that it’s has been demonstrated to be poisonous to each non-celiacs and celiacs. 


Gliadin upregulates the manufacturing of a protein referred to as zonulin, which modulates intestinal permeability. Over-expression of zonulin is concerned in a quantity of autoimmune issues, together with celiac illness and Sort 1 diabetes. Researchers have studied the impact of gliadin on elevated zonulin manufacturing and subsequent intestine permeability in each celiac and non-celiac intestines, and have discovered that “gliadin activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.”10 These outcomes point out, as soon as once more, that a pathological response to wheat gluten is a traditional or human, species particular response, and just isn’t based mostly completely on genetic susceptibilities. As a result of intestinal permeability is related to wide selection of illness states, together with cardiovascular sickness, liver illness and many autoimmune issues, I consider this analysis signifies that gliadin (and subsequently wheat) ought to be prevented as a matter of precept.


Gliadin might be damaged down into numerous amino acid lengths or peptides. Gliadorphin is a 7 amino acid lengthy peptide: Tyr-Professional-Gln-Professional-Gln-Professional-Phe which types when the gastrointestinal system is compromised. When digestive enzymes are inadequate to interrupt gliadorphin down into 2-Three amino acid lengths and a compromised intestinal wall permits for the leakage of your complete 7 amino acid lengthy fragment into the blood, glaidorphin can cross via to the mind by means of circumventricular organs and activate opioid receptors leading to disrupted mind perform. 

There have been a quantity of gluten exorphins recognized: gluten exorphin A4, A5, B4, B5 and C, and many of them have been hypothesized to play a task in autism, schizophrenia, ADHD and associated neurological circumstances. In the identical approach that the celiac iceberg illustrated the phantasm that intolerance to wheat is uncommon, it’s attainable, even possible, that wheat exerts pharmacological influences on everybody. What distinguishes the schizophrenic or autistic particular person from the practical wheat shopper is the diploma to which they’re affected.

Under the tip of the “Gluten Iceberg,” we’d discover these opiate-like peptides to be answerable for bread’s basic reputation as a “comfort food”, and our use of phrases like “I love bread,” or “this bread is to die for” to be indicative of wheat’s narcotic properties. I consider a robust argument may be made that the agricultural revolution that occurred roughly 10-12,000 years in the past as we shifted from the Paleolithic into the Neolithic period was precipitated as a lot by environmental requirements and human ingenuity, because it was by the addictive qualities of psychoactive peptides within the grains themselves.  

The world-historical reorganization of society, tradition and consciousness completed via the symbiotic relationship with cereal grasses, might have had as a lot to do with our capability to grasp agriculture, as to be mastered by it. The presence of pharmacologically lively peptides would have additional sweetened the deal, making it exhausting to distance ourselves from what turned a worldwide fascination with wheat.

An fascinating instance of wheat’s addictive potential pertains to the Roman military. The Roman Empire was as soon as often known as the “Wheat Empire,” with troopers being paid in wheat rations. Rome’s complete conflict machine, and its huge enlargement, was predicated on the supply of wheat. Forts have been truly granaries, holding as much as a yr’s value of grain in an effort to endure sieges from their enemies. Historians describe troopers’ punishment included being disadvantaged of wheat rations and being given barley as an alternative.   The Roman Empire went on to facilitate the worldwide dissemination of wheat cultivation which fostered a type of imperialism with organic in addition to cultural roots.

The Roman appreciation for wheat, like our personal, might have had much less to do with its dietary worth as “health food” than its capacity to generate a singular narcotic response. It might fulfill our starvation whereas producing a repetitive, ceaseless cycle of craving extra of the identical, and by doing so, enabling the surreptitious management of human conduct. Different researchers have come to comparable conclusions. Based on the biologists Greg Wadley & Angus Martin:

“Cereals have important qualities that differentiate them from most other drugs. They are a food source as well as a drug, and can be stored and transported easily. They are ingested in frequent small doses (not occasional large ones), and do not impede work performance in most people. A desire for the drug, even cravings or withdrawal, can be confused with hunger. These features make cereals the ideal facilitator of civilization (and may also have contributed to the long delay in recognizing their pharmacological properties).”


Wheat incorporates a lectin generally known as Wheat Germ Agglutinin which is chargeable for inflicting direct, non-immune mediated injury to our intestines, and subsequent to entry into the bloodstream, injury to distant organs in our physique. 

Lectins are sugar-binding proteins that are extremely selective for his or her sugar moieties. It’s believed that wheat lectin, which binds to the monosaccharide N-acetyl glucosamine (NAG), supplies protection towards predation from micro organism, bugs and animals. Micro organism have NAG of their cell wall, bugs have an exoskeleton composed of polymers of NAG referred to as chitin, and the epithelial tissue of mammals, e.g. gastrointestinal tract, have a “sugar coat” referred to as the glycocalyx which consists, partially, of NAG. The glycocalyx might be discovered on the outer floor (apical portion) of the microvilli inside the small gut.

There’s proof that WGA might trigger elevated shedding of the intestinal brush border membrane, discount in floor space, acceleration of cell losses and shortening of villi, by way of binding to the floor of the villi. WGA can mimic the consequences of epidermal progress issue (EGF) on the mobile degree, indicating that the crypt hyperplasia seen in celiac illness could also be on account of a mitogenic reponse induced by WGA. WGA has been implicated in weight problems and “leptin resistance” by blocking the receptor within the hypothalamus for the urge for food satiating hormone leptin. WGA has additionally been proven to have an insulin-mimetic motion, probably contributing to weight achieve and insulin resistance.15 And, as mentioned earlier, wheat lectin has been proven to induce IgA mediated injury to the kidney, indicating that nephropathy and kidney most cancers could also be related to wheat consumption.


Gliadorphin and gluten exporphins exhibit a type of molecular mimicry that impacts the nervous system, however different wheat proteins impact totally different organ techniques. The digestion of gliadin produces a peptide that’s 33 amino acids lengthy and is called 33-mer which has a exceptional homology to the interior sequence of pertactin, the immunodominant sequence within the Bordetella pertussis micro organism (whooping cough). Pertactin is taken into account a extremely immunogenic virulence issue, and is utilized in vaccines to amplify the adaptive immune response. It’s attainable the immune system might confuse this 33-mer with a pathogen leading to both or each a cell-mediated and adaptive immune response towards Self.  


John B. Symes, D.V.M. is chargeable for drawing consideration to the potential excitotoxicity of wheat, dairy, and soy, resulting from their exceptionally excessive ranges of the non-essential amino acids glutamic and aspartic acid. Excitotoxicity is a pathological course of the place glutamic and aspartic acid trigger an over-activation of the nerve cell receptors (e.g. NMDA and AMPA receptor) resulting in calcium induced nerve and mind damage. Of all cereal grasses generally consumed wheat incorporates the very best ranges of glutamic acid and aspartic acid. Glutamic acid is essentially chargeable for wheat’s distinctive style. The Japanese coined the phrase umami to explain the extraordinary “yummy” impact that glutamic acid exerts on the tongue and palate, and invented monosodium glutamate (MSG) to amplify this sensation. Although the Japanese first synthesized MSG from kelp, wheat can be used because of its excessive glutamic acid content material. It’s probably that wheat’s reputation, alongside its opiate-like exercise, has every little thing to do with the pure flavor-enhancers already contained inside it. These amino acids might contribute to neurodegenerative circumstances reminiscent of a number of sclerosis, Alzhemier illness, Huntington’s illness, and different nervous issues akin to epilepsy, consideration deficit dysfunction and migraines.


On this article I’ve proposed that celiac illness be seen not as a uncommon “genetically-determined” dysfunction, however as an excessive instance of our physique speaking to us a as soon as common, species-specific affliction: extreme intolerance to wheat. Celiac illness displays again to us how profoundly our food regimen has diverged from what was, till solely just lately a grain free food plan, and much more lately, a wheat free one. We’re so profoundly distanced from that dramatic Neolithic transition in cultural time that “missing is any sense that anything is missing.” The physique, however, can’t assist however keep in mind a time when cereal grains have been alien to the weight-reduction plan, as a result of in organic time it was solely moments in the past.

Eliminating wheat, if not all of the members of the cereal grass household, and returning to dicotyledons or pseudo-grains like quinoa, buckwheat and amaranth, might assist us roll again the arms of organic and cultural time, to a time of readability, well being and vitality that many of us have by no means recognized earlier than. When one eliminates wheat and fills the void left by its absence with fruits, greens, top quality meats and meals in keeping with our organic wants we might start to really feel a way of vitality that many would discover exhausting to think about. If wheat actually is extra like a drug than a meals, anesthetizing us to its unwell results on our physique, it is going to be troublesome for us to know its grasp upon us until and till we get rid of it from our food plan. I encourage everybody to see celiac illness not as a situation alien to our personal. Somewhat, the celiac provides us a glimpse of how profoundly wheat might distort and disfigure our well being if we proceed to show ourselves to its unwell results. I hope this text will present inspiration for non-celiacs to attempt a wheat free food plan and decide for themselves whether it is actually value eliminating.  

A critically acclaimed web basic, The Dark Side of Wheat is now obtainable to personal as a downloadable doc solely from GreenMedInfo.com. Members obtain it free, together with $300 of further content material. It consists of two hard-hitting essays that characterize a seachange in the best way wheat intolerance is comprehended; not a uncommon, strictly genetically-based illness, wheat is revealed to be a species-specific intolerance, whose position in well being and illness has been significantly misunderstood since historic occasions. The downloadable doc additionally features a 90-page fast reference information containing hyperlinks to analysis on the Nationwide Library of Drugs on over 120 illnesses which were linked to wheat consumption.

The Dark Side of Wheat has modified many minds concerning the exalted standing of wheat amongst secular and sacred establishments alike.

As Dr. Ron Hoggan, co-author of “Dangerous Grains” places it within the foreword: “Sir Isaac Newton’s famous metaphor (perhaps quoting others) said something to the effect that we see further, not because of any special endowment of our own, but because we are standing on the shoulders of giants. After reading Sayer’s work on wheat, I felt as if I had just been boosted to a higher plane from which I could see and understand much, much more. Sayer’s insights continue to shape and inform much of my effort to understand the various impacts of grains on human health.”

Click on right here to learn a pattern of this doc.


* Genome screening of coeliac illness

1 Celiac illness: an rising international drawback Journal of Pediatric Gastroenterology and Vitamin 2002 Oct; 35 (Four): 472-Four

2 Richard Logan is answerable for first introducing the “Celiac Iceberg” metaphor in 1991

Three Antibody testing for gliadin, tissue transglutaminase and endomysium signifies that “silent” or “latent” celiac illness is as much as a 100 occasions extra frequent than represented by the classical type.

Four Frontiers in Celiac Disease by Alessio Fasano, R. Troncone, D. Branski  Revealed by Karger Publishers, pg. 242

5 See: www.patienthealthyself.information/Cystic_Fibrosis.html for Medline citations.

6 Cystic Fibrosis: a perinatal manifestation of selenium deficiency. Wallach JD, Germaise B. In: Hemphill DD, ed. Hint substances in environmental well being. Columbia: College of Missouri Press, 1979; 469-76

7 Genetic dissection between silent and clinically recognized symptomatic varieties of coeliac illness in multiplex  households. Digestive and Liver Disease 2002 Dec;34(12):842-5.

eight “Coelionomics”: in the direction of understanding the molecular pathology of coeliac illness. Medical Chemistry and Laboratory Drugs 2005;43(7):685-95.

9 Is gliadin actually protected for non-coeliac people? Intestine 2007;56:889-890; doi:10.1136/intestine.2006.

10 “Do Dietary Lectins cause disease?” David L J Freed, BMJ 1999;318:1023-1024

11 “Food groups and renal cell carcinoma: a case-control study from Italy.” Worldwide Journal of Most cancers 2007 Feb 1;120(Three):681-5.

12 Unglued: The Sticky Fact About Wheat, Dairy, Corn and Soy. Scott-Free Publication, Autumn 2008

13 Exploring the Plant Transcriptome by way of Phylogenetic Profiling. Plant Physiology Vol. 137, 2005; pg. 33

14 An Introduction to Genetic Engineering. By Desmond S. T. Nicholl, Cambridge College Press, 2002, pg. 24

15 Genetic dissection between silent and clinically recognized symptomatic varieties of coeliac illness in multiplex  households. Digestive and Liver Disease 2002 Dec;34(12):842-5.

16 “Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell  lines.” Scandinavian Journal of Gastroenterology Apr;41(Four):408-19.

17 “The origins of agriculture ? a biological perspective and a new hypothesis” by Greg Wadley & Angus Martin,Australian Biologist 6:96- 105, June 1993

18 In vivo responses of rat intestinal epithelium to intraluminal dietary lectins. Gastroenterology. 1982 Might;82(5 Pt 1):838-48.

19 Elevated ranges of serum antibodies to the lectin wheat germ agglutinin in celiac youngsters lend help to the  gluten-lectin concept of celiac illness. Pediatric Allergy Immunology 1995 Might;6(2):98-102.

20 Agrarian weight loss plan and illnesses of affluence – Do evolutionary novel dietary lectins trigger leptin resistance BMC Endocrine Issues 2005, 5:10

21 Insulin-mimetic actions of wheat germ agglutinin and concanavalin A on particular mRNA ranges. Archives of Biochemistry and Biophysics 1987 Apr;254(1):110-5.

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